HRT
Note: after around a month on HRT some of your ranges in your blood test (γενική αίματος) should be in the ranges of the sex you are transitioning into.
If you are a transfem: no, its not anemia
MTF
THERE IS NO GOOD REASON TO TAKE ONLY PUBERTY BLOCKERS (gnrh agonists, eg: arvekap) OR ANY ANTIANDROGEN WITHOUT ESTROGEN (i say this about youth transitioners, not nb ppl)
Monotherapy
| Είδος | Εμπορικά Ονόματα | Δοσολογία | Notes |
|---|---|---|---|
| Υπογλώσσια/Sublingual (E Valerate/Βαλεριανική ή Hemihydrate/Ημιένυδρη) | Cyclacur (EV), Estrofem (EH) | >=8-12mg/μέρα | Ενώ είναι εφικτό και με μικρότερη δοσολογία (τουλάχιστον 6mg), δεν είναι τόσο σύνηθες. Καλό είναι οι εξετάσεις αίματος ως σημείο αναφοράς για αυξομειώσεις (το γνωστό "Minmaxing") |
| Ενέσιμη Ενανθική (EEn) |  |
4-7mg/Εβδομάδα
7-10mg/10 μέρες (7.2mg συνήθως, αναλόγως το φιαλίδιο, βολεύει διότι οι εκατοντάδες των mL είναι δύσκολες να βγούν ακριβώς) |
|
| Ενέσιμη Ενδεκυλική (EU/EUn) | |
Δεν υπάρχουν αρκετές πληροφορίες για τις δοσολογίες. Η συχνότητα των διαφέρει ανάλογα το λάδι (MCT/καστορέλαιο). Ενδεικτικές δοσολογίες:
15-20mg/2 εβδομάδες 20-40mg+/4 εβδομάδες |
|
* = Έχει αναφερθεί πως οι σύριγγες υπολογίζουν το dead space, αλλά δεν είναι 100% σίγουρο αυτό.
Sublingual vs oral
| Μέθοδος | Ουσία | Δοσολογία | Παρατηρήσεις |
|---|---|---|---|
| Oral (Κατάποση) | Estradiol Valerate σε μορφή χαπιού (πχ Cyclacur) | >=6mg/μέρα
(max 10mg as per Dr. Powers) |
Οι δόσεις συνιστάται να γίνονται ξεχωριστά ανά τακτά χρονικά διαστήματα εντός της μέρας για πιο σταθερά επίπεδα οιστραδιόλης, πχ για δοσολογία 6mg παίρνουμε 2mg ανά 8 ώρες. Με την oral δίοδο η δραστική ουσία μεταβολίζεται από το συκώτι και ένα τμήμα της μετατρέπεται σε εστρόνη (Ε1), η οπoία έχει πολύ μικρότερα feminizing effects από την οιστραδιόλη (Ε2) οπότε εμποδίζεται ουσιαστικά το επιθυμητό αποτέλεσμα. Η βιοδιαθεσιμότητα της οιστραδιόλης με oral χορήγηση είναι πολύ μικρή (~5%) και συνήθως παρατηρούνται χαμηλότερα επίπεδα Ε2 σε εξετάσεις αίματος από τις υπόλοιπες μεθόδους χορήγησης. [anecdotal apo to server, wikipedia kai tttt - correct/expand?] Χρειάζεται παράλληλα να γίνεται χορήγηση αντιανδρογόνων για να μειωθούν τα επίπεδα τεστοστερόνης σε female range. |
| Sublingual (Υπογλώσσια) | Estradiol Valerate σε μορφή χαπιού (πχ Cyclacur) | >=4mg/μέρα | Οι δόσεις συνιστάται να γίνονται ξεχωριστά ανά τακτά χρονικά διαστήματα εντός της μέρας για πιο σταθερά επίπεδα οιστραδιόλης, πχ για δοσολογία 6mg παίρνουμε 2mg ανά 8 ώρες. Η υπογλώσσια δίοδος παρακάμπτει τον μεταβολισμό της οιστραδιόλης από το συκώτι και έχει περίπου 5 φορές τη βιοδιαθεσιμότητα οιστραδιόλης από την oral δίοδο. Με την υπογλώσσια μέθοδο τα επίπεδα οιστραδιόλης έχουν μεγαλύτερη διακύμανση από orally (higher peak lower bottom), με oral παραμένουν αυξημένα για ~12 ώρες ενώ με sublingual υποχωρούν μετά από 3-4 ώρες [idk if honscience to study einai apo to 2005 se cis gynaikes] |
Vial info
Medications
For cyclacur: take only the white pills, the brown pills are Norgestrel which has an androgenic effect and may also cause other side effects.
Estrogen:
| Εμπορικό Όνομα | Ουσία | Κόστος | Κόστος με ασφάλιση | Δοσολογία | Safety | Notes |
|---|---|---|---|---|---|---|
| Cyclacur | Estradiol Valerate (aka: EV, Βαλεριανική Οιστραδιόλη)
(Σε χάπι) |
1.69/per 11 pills
~111-277 euro/year (depending on the dosage) ~9.3-23.1 euro/month (depending on the dosage) |
- | 6mg-10mg/day (per Dr. Will Powers)
4mg-8mg/day (Greek average) |
A | ONLY THE WHITE PILLS
Needs an anti-androgen or a gnrh agonist if not undergone orchiectomy |
| Estradiol Enanthate (aka: EEn) | 80 euro/year (including transport, syringes, and medical alcohol wipes) | - | 2.5mg/7days ~ 7mg/7days
(usual: 4mg/7days) |
A+ | ||
| Estradiol Undecylate (aka: EU, EUn) | 130 euro/year (including transport, syringes, and medical alcohol wipes) | - | A+ |
Anti-androgens and GNRH Agonists
These should not be taken sublingually.
| Εμπορικό Όνομα | Ουσία | Κόστος | Κόστος με ασφάλιση | Δοσολογία | Safety | Method | Type | Notes |
|---|---|---|---|---|---|---|---|---|
| Androcur | Cyproterone acetate (aka: CPA, aka: cypro, (Οξεική) Κυπροτερόνη) | 23.10 euro/50mg * 50 pills
23.10-46.2/year |
? | 6mg/2days - 12.5mg/day
Do not take higher dosages |
C | Pill | Progestin (Steroidal antiandrogen)
Stops testosterone production |
Prolonged use of dosages higher than 12.5mg/day may cause brain tumors.
IF YOUR DOCTOR PRESCRIBES YOU 50mg/day SWITCH DOCTORS IMMEDIATELY Very rare chance for liver damage. Note: lower dosages are very much possible, but they are not included because splitting the pill more would be annoying and there isn't a pill smaller than 50mg. |
| Bicalut | Bicalutamide (aka: bica, Βικαλουταμίδη) | 29.10 euro/30 pills
29.10/month ~350/year |
6.77 euro/month (28 tabs)
~95/year |
50mg/day | A- | Pill/Tablet | Androgen receptor antagonist (Nonsteroidal antiandrogen)
Blocks absorption of all androgens (including testosterone) |
Serious negative interactions can be noted if combined with other anti-androgens and GNRH agonists (except progesterone)
Very rare chance for recoverable and non-fatal liver damage for people with a certain rare mutation. Most of the effects listen in the instruction manual are scaremongering. (it lists a very high chance of liver issues when they are actually very rare, and also lists photosensitivity, which if it even occurs at all, it should be quite rare. We are aware of nobody who had a negative interction between alexandrite laser hair removal and bicalutamide). Note that bicalutamide, unlike most other anti-androgens, does not lower testosterone levels, in fact they usually rise as the body responds to testosterone receptors being inhibited. Do not be alarmed if you notice an increase of testosterone in your blood tests. |
| Utrogestan | Progesterone (aka: Prog, Προγεστερόνη) | 6.56 euro/15 caps (200mg) | ? | 200mg daily, rectally | A | Capsule | Stops testosterone production | Shouldn't be taken until after 1 year on estrogen.
Should never be taken orally. May have androgenic or other (non-serious, recoverable) effects for some people - specifically it can be converted to DHT by your body. Often combined with dutasteride or bicalutamide as other anti-androgens will not stop it. Is supposed to help with feminization (including breast growth) |
| Arvekap | Triptorelin (Τριπτορελίνη) | - | ~200/year? | A? | Injection | GNRH Agonist
(indirectly) Stops testosterone AND estrogen production |
Also a puberty blocker | |
| Aldactone | Spironolactone (Σπειρονολακτόνη) | 5.19 euro/20 tabs (100mg) | ? | 50mg-200mg/day | B-C | Tablet | Very inefficient, makes you pee, it's a medication for blood pressure | |
| Flutamide (Φλουταμίδη) | F--- | Only in this table as an example to avoid |
Other anti-androgens (optional)
These are used to block conversion of other androgens to DHT (which causes hair loss (hair) and body hair growth). They aren't general use anti-androgens.
| Name | Effectiveness | ||
|---|---|---|---|
| Dutasteride | High | ||
| Finasteride | None to Medium (Please just take duta - will not stop conversion of progesterone to DHT) |
Blood Levels
PLEASE make sure that you are using the right measures
Careful: biotin can mess with blood tests and make everything seem much higher
Grapefruit fucks everything
Do the test JUST BEFORE your next dosage
E2: - pg/ml
Some doctors claim that it should be 100-200 pg/ml, this is not scientifically supported.
T: <1.5nmol/L (ng/??)
DHT: <10? (High values signify an issue but low values don't signify lack of an issue, DHT is often created inside of tissues and doesn't leak to blood)
If taking Androcur (Cyproterone acetate), also check: Prolactin
If taking either Androcur (Cyproterone acetate) or Bicalutamide, also check: ALT, AST. As an extra if you feel like wasting money: Bilirubin, ???
FTM
Legal
It is legal to buy anything without a diagnosis or a prescription (off the counter - OTC) EXCEPT testosterone
There is no minimum or maximum legal age for someone to start HRT.
It is not legally mandatory for someone to have a diagnosis by a psychiatrist in order to medically transition.
There is no legally mandatory time restriction for a psychiatrist to monitor you before diagnosing you.
You don't legally need to be on HRT in order to be exempt from the army, change your legal sex, or to have a surgery.
Other resources
- Simulator: https://www.estrannai.se/
- https://transfemscience.org/ (note, the authors of this site disagree with a lot of what they are saying, regardless, it is still interesting)
- Introduction to Hormone Therapy for Transfeminine People: https://transfemscience.org/articles/transfem-intro/
- Older simulator: https://transfemscience.org/misc/injectable-e2-simulator/
- Dosage calculator: https://transfemscience.org/misc/injectable-dose-vol-conc-conv/
- https://diyhrt.wiki/
- https://hrtcafe.net/
- ?? https://hrt.coffee/
- https://www.reddit.com/r/TransDIY/
- https://www.reddit.com/r/TransfemScience/
